Recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings

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Recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings.

The activation and recovery phases of the murine rod photo-response were determined from corneal electroretinograms (ERGs) obtained in response to pairs of full-field flashes producing 50-10(5) photoisomerized rhodopsins (R*) per rod. The a-wave component of the ERG in response to the initial flash provided a well established measure of the activation phase of the rod response. The amplitude of...

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Recovery of the rod photoresponse in infants.

PURPOSE To study deactivation of the rod photoresponse in infants using a paired-flash procedure. Rhodopsin content increases and scales the parameters of the activation of rod phototransduction as rods develop. However, little is known about the kinetics of deactivation in the rods of young infants. METHODS ERG responses to pairs of flashes were used to study the recovery of the rod response...

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Kinetics of Recovery of the Dark-adapted Salamander Rod Photoresponse

The kinetics of the dark-adapted salamander rod photocurrent response to flashes producing from 10 to 10(5) photoisomerizations (Phi) were investigated in normal Ringer's solution, and in a choline solution that clamps calcium near its resting level. For saturating intensities ranging from approximately 10(2) to 10(4) Phi, the recovery phases of the responses in choline were nearly invariant in...

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Recovery of the rod photoresponse in infant rats

We tested the hypothesis that the kinetics of recovery of the rod photoresponse differ between mature and immature rods. A paired flash paradigm was used. The effect of a test flash on the ERG a-wave response to a probe flash presented 60 to 2 s after the test flash was studied. The functions summarizing the interaction between the test and probe flash did not differ significantly between infan...

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Calcium Sets the Physiological Value of the Dominant Time Constant of Saturated Mouse Rod Photoresponse Recovery

BACKGROUND The rate-limiting step that determines the dominant time constant (τ(D)) of mammalian rod photoresponse recovery is the deactivation of the active phosphodiesterase (PDE6). Physiologically relevant Ca(2+)-dependent mechanisms that would affect the PDE inactivation have not been identified. However, recently it has been shown that τ(D) is modulated by background light in mouse rods. ...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1996

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.16-02-00563.1996